MO831PROGNOSIS OF HEPATOCELLULAR CARCINOMA IN HEMODIALYSIS PATIENTS
نویسندگان
چکیده
Abstract Background and Aims The aim of this study was to compare the prognosis hepatocellular carcinoma (HCC) between dialysis non-dialysis patients. Method In retrospective observational study, we examined consecutive patients with naïve localized HCC, who were treated radiofrequency ablation (RFA) February 2000 December 2017. categorized into two subgroups based on whether they maintenance (Dialysis Group, n=458) or not (Non-dialysis n=13), followed until 2019. primary endpoint overall survival using Kaplan-Meier analysis. As for propensity score matching, matched 13 pairs cases by age, sex, Child-Pugh score, tumor size, number tumors HCV positivity. We also compared causes death 2 groups. Results cohort aged 69.9±9.1 years included 328 male (70%). Hepatitis B positive in 37 (7.9%), C 322 (68.4%) co-infection HBV detected 3 (0.6%). Ninety-five (20.2%) heavy alcohol drinkers. Dialysis younger (p=0.004), total bilirubin, AST, ALT levels significantly lower PT level higher. entire cohort, comparable Group Non-dialysis (5-year rate 55.2% vs 52.7%, respectively; p =0.144). matching analysis, however, showed worse than 52.7% 92.3%, =0.018). During period, 255 (54%) died. death, liver-related occurred 44% 67% whereas cardiovascular 22% 5% Group. Procedure-related major complication first RFA session each patient 0% Conclusion Prognosis poorer ones, which may be explained a higher non-liver-related population. Since RFA, per se, has been safely preformed patients, prognostic improvement expected treating HCC as aggressively cases.
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2021
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfab098.0023